„SARS-CoV-2 viruses binding to ACE-2 receptors on a human cell, the initial stage of COVID-19 infection, conceptual 3D illustration credit: Kateryna Kon / Shutterstock“
„Novel coronavirus attacks and destroys T cells, just like HIV
By Angela Betsaida B. Laguipo, BSNApr 13 2020
The immune system has many components that work together in protecting the body from foreign invaders. One of the most important types of immune cells is T lymphocytes or T cells, a type of white blood cell that acts as the core of adaptive immunity, the system that modifies the immune response to specific pathogens.
T-lymphocytes attack a colony of fungi. Image Credit: UGREEN 3S / Shutterstock
Now, a team from the United States and China revealed evidence that the coronavirus disease, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), attacks the immune system’s T lymphocytes. The worrying findings highlight the destructive power of the novel coronavirus, which can destroy the immune system, leaving the patient unable to fight off the infection.
The novel coronavirus:
Coronaviruses have been causing problems in humans for a long time. Though many versions of the virus are known to trigger only mild symptoms such as common colds. However, three recent types of coronavirus have caused deadly diseases – the severe acute respiratory syndrome (SARS) in China in 2002, the Middle East respiratory syndrome (MERS) in Saudi Arabia in 2012, and the current global pandemic, the coronavirus disease (COVID-19), which first emerged in Wuhan City, Hubei Province, in China December 2019.
The impact of the previous coronavirus outbreaks in 2002 and 2012 has been mild compared with the mayhem unleashed by the SARS-CoV-2. Within only a few months, the novel coronavirus has prompted most countries to go into lockdown, dwindling economies, and overwhelming health care systems with the more than 2 million people infected.
… Now, the researchers’ surprise discovery has shed light on the potency of the novel coronavirus is killing powerful immune cells, which are supposed to kill the virus instead.
Novel Coronavirus SARS-CoV-2 Colorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (purple), isolated from a patient sample. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID
Novel Coronavirus SARS-CoV-2 Colorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (purple), isolated from a patient sample. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland.
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COVID-19 and renin-angiotensin system inhibitors
The researchers from the Fudan University in Shanghai, China, and the New York Blood Centre, has studied the virus’s action on T-lymphocyte cell lines. T lymphocytes or T cells work by identifying and eliminating foreign invaders in the body.
To arrive at their findings, published in the journal of Cellular & Molecular Immunology, the team captured a cell infected by the virus, penetrated the membrane, and injected toxic chemicals into the cell. After this, the chemicals killed both the virus and infected cells by tearing them into pieces.
Surprisingly, the team has found that when the coronavirus and the T cell came into contact with each other, the T cell became prey to the coronavirus, wherein a structure in the spike of the coronavirus triggered the attachment of a viral envelope and the cell membrane. After, the genes of the virus entered the T cell and overwhelmed it, took it hostage, and deactivated its ability to protect the body.
The team then tried to do the same with the SARS virus, and another coronavirus, but these pathogens were not able to infect T cells. The researchers suspect that the SARS virus, which caused an outbreak in 2002 to 2003, has a lack of a membrane fusion function. The virus can only infect cells that have a particular receptor protein called the angiotensin-converting enzyme 2 (ACE2). T cells contain only a few ACE2 receptor proteins.
It is an important discovery, knowing the effect of the SARS-CoV-2 on T cells, since this may show why the disease is spreading so quickly, and infecting so many across the globe. It also explains why certain vulnerable populations are at a high risk of dying from the infection, including those who are more than 65, those who are immunocompromised, and those with underlying medical conditions like lung disease, heart disease, diabetes, and hypertension.
Further investigation shows that patients who died from COVID-19 had damage to their bodies similar to both SARS and HIV. Also, the team found that unlike HIV that replicates faulty T cells, the coronavirus does not replicate, showing that the T cells and the virus may end up dying together.
Source:
COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). (2020). https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html
Journal reference:
Xia, S., Liu, M., Wang, C., Xu, W., Lan, Q., Feng, S., Lu, L. et al. (2020). Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cellular & Molecular Immunology.“
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North Carolina woman gets coronavirus despite staying home for three weeks
„North Carolina woman gets coronavirus despite staying home for three weeks“
Victoria Nissen: so is it in the air? As in Chemtrails?
Nadine Nelson: Incubation is up to a month and yes it´s also Airborne, so maybe neighbours.
Julia Rose: on the shopping.
Tim Casey: She had an autoimmune disorder, anyone with an autoimmune disorder will test positive for covid-19.
The test for covid-19, tests for enzymes realised from cell death. So autoimmune diseases, stress, cancer, heart
disease, and many other things will test positive.
Danielle Rae: There is some BS here. So let’s start living again and all get it.
If we die, we die.. fuck it at this point.
Lori Dalton: Try reading the article. She let someone deliver groceries she didn’t know, who had it. Then she didn’t take it out of the bags or clean it, before she brought it inside.
Greg R. Dietrich: Ahh! the ny post.
Eric Lopez: That’s at least what she told her husband and the media.
Jody Bacon Sanders: 5G.
Puti Warbrick: False positive test.
Krisztina Halász: Coronavirus is the common cold. New strand is covid19.
So. Every covid19 is coronavirus, but not every corona is covid! But test can only confirm the common coronavirus..
So you can be positive, but not have the new strand!
„A North Carolina coronavirus patient said she was infected despite staying home for the three weeks leading up to her diagnosis last Thursday, a report said.
“This is the sickest I’ve ever been and it’s the most scared I’ve ever been,” Rachel Brummert told WCNC. “I’m absolutely terrified.”
Brummert, who suffers from an autoimmune disorder, told the outlet that she last left her Charlotte home for a trip to the pharmacy in mid-March.
Because of her underlying condition, Brummert, as a precautionary measure, had kept her distance from others, including her husband, who is living in a separate room.
Enlarge ImageRachel Brummert
Rachel BrummertTwitter
On one occasion, a woman who has since tested positive for the illness dropped off groceries on Brummert’s doorstep, the report said.
While Brummert didn’t come into contact with the woman, she said she retrieved the bags of food from her porch without gloves.
“I really thought I was doing everything right,” Brummert said.
“I’ve never had anything like this before,” she said. “I’ve had the flu. This is not the flu. It’s a whole other monster.”“
Source: https://nypost.com/2020/04/13/nc-woman-gets-covid-19-despite-staying-home-for-three-weeks/
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Loss of smell and taste validated as COVID-19 symptoms in patients with high recovery rate
„Loss of smell and taste validated as COVID-19 symptoms in patients with high recovery rate“
„Neuroscience News
14 hours ago
Summary: Study confirms sensory loss associated with taste and smell is strongly linked to early coronavirus infection. Based on the findings, people who report olfactory or taste loss are ten times more likely to have COVID-19 than other infections. Patients reported their sensory loss to be profound rather than mild. Encouragingly, the rate of sensory recovery was high, with patients reporting a return of normal smell and taste function within two to four weeks, which matches the time of disease recovery. Researchers also found people who reported sore throats more often tested negative for COVID-19.
Source: UCSD“
„Loss of smell and taste has been anecdotally linked to COVID-19 infections. In a study published April 12, 2020 in the journal International Forum of Allergy & Rhinology, researchers at UC San Diego Health report the first empirical findings that strongly associate sensory loss with COVID-19, the respiratory disease caused by the novel coronavirus.
“Based on our study, if you have smell and taste loss, you are more than 10 times more likely to have COVID-19 infection than other causes of infection. The most common first sign of a COVID-19 infection remains fever, but fatigue and loss of smell and taste follow as other very common initial symptoms,” said Carol Yan, MD, an otolaryngologist and head and neck surgeon at UC San Diego Health. “We know COVID-19 is an extremely contagious virus. This study supports the need to be aware of smell and taste loss as early signs of COVID-19.”
Yan and colleagues surveyed 1,480 patients with flu-like symptoms and concerns regarding potential COVID-19 infection who underwent testing at UC San Diego Health from March 3 through March 29, 2020. Within that total, 102 patients tested positive for the virus and 1,378 tested negative. The study included responses from 59 COVID-19-positive patients and 203 COVID-19-negative patients.
Yan said the study demonstrated the high prevalence and unique presentation of certain sensory impairments in patients positive with COVID-19. Of those who reported loss of smell and taste, the loss was typically profound, not mild. But encouragingly, the rate of recovery of smell and taste was high and occurred usually within two to four weeks of infection.
“Our study not only showed that the high incidence of smell and taste is specific to COVID-19 infection, but we fortunately also found that for the majority of people sensory recovery was generally rapid,” said Yan. “Among the Covid-19 patients with smell loss, more than 70 percent had reported improvement of smell at the time of survey and of those who hadn’t reported improvement, many had only been diagnosed recently.”“
But encouragingly, the rate of recovery of smell and taste was high and occurred usually within two to four weeks of infection. The image is in the public domain.
Sensory return typically matched the timing of disease recovery. Interestingly, the researchers found that persons who reported experiencing a sore throat more often tested negative for COVID-19.
In an effort to decrease risk of virus transmission, UC San Diego Health now includes loss of smell and taste as a screening requirement for visitors and staff, as well as a marker for testing patients who may be positive for the virus.
Other known symptoms of COVID-19 include fever, fatigue, cough and difficulty breathing. Respondents in Yan’s study were most often persons with milder forms of COVID-19 infection who did not require hospitalization or intubation. The findings, she said, underline the importance of identifying early or subtle symptoms of COVID-19 infection in people who may be at risk of transmitting the disease as they recuperate within the community.
“It is our hope that with these findings other institutions will follow suit and not only list smell and taste loss as a symptom of COVID-19, but use it as a screening measure for the virus across the world,” Yan said.
…
Source: UCSD
Media Contacts: Jeanna Vazquez – UCSD
Image Source: The image is in the public domain.
…
International Forum of Allergy and Rhinology
Abstract
Long-term memory performance depends upon gating system
Association of chemosensory dysfunction and Covid‐19 in patients presenting with influenza‐like symptoms
Background
Rapid spread of the SARS‐CoV‐2 virus and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of Covid‐19 infection. Two such candidate symptoms include anecdotally reported loss of smell and taste. Understanding the timing and association of smell/taste loss in Covid‐19 may help facilitate screening and early isolation of cases.
Methods
A single‐institution, cross‐sectional study evaluating patient‐reported symptoms with a focus on smell and taste was conducted using an internet‐based platform on adult subjects who underwent testing for Covid‐19. Logistic regression was employed to identify symptoms associated with Covid‐19 positivity.
Results
A total of 1480 patients with influenza‐like symptoms underwent Covid‐19 testing between March 3 through 29, 2020. Our study captured 59 of 102 (58%) Covid‐19‐positive patients and 203 of 1378 (15%) Covid‐19‐negative patients. Smell and taste loss were reported in 68% (40/59) and 71% (42/59) of Covid‐19‐positive subjects, respectively, compared to 16% (33/203) and 17% (35/203) of Covid‐19‐negative patients..
Conclusions
In ambulatory individuals with influenza‐like symptoms, chemosensory dysfunction was strongly associated with Covid‐19 infection and should be considered when screening symptoms. Most will recover chemosensory function within weeks paralleling resolution of other disease‐related symptoms.“
Source: https://neurosciencenews.com/smell-taste-covid-19-recovery-16149/ -
Coronavirus could attack immune system like HIV by targeting protective cells
Conspiracy Revelation: 13.4.2020: Sure IT IS QUASI HIV+SARS = DEVASTATING NWO DOUBLE BIOWEAPON. REPTILIANS have no problems with HIV, be sure.
„China / Society
Coronavirus could attack immune system like HIV by targeting protective cells, warn scientists
Researchers in China and the US find that the virus that causes Covid-19 can destroy the T cells that are supposed to protect the body from harmful invaders
One doctor said concern is growing in medical circles that effect could be similar to HIV.“
„The reason, they suspected, was the lack of a membrane fusion function. Sars, which killed hundreds in a 2003 outbreak, can only infect cells carrying a specific receptor protein known as ACE2, and this protein has an extremely low presence in T cells.
Further investigations to the coronavirus infection on primary T cells would evoke “new ideas about pathogenic mechanisms and therapeutic interventions,” the researchers said in a paper published in the peer-reviewed journal Cellular & Molecular Immunology this week.
A doctor, who works in a public hospital treating Covid-19 patients in Beijing, said the discovery added another piece of evidence to a growing concern in medical circles that the coronavirus could sometimes behave like some of the most notorious viruses that directly attack the human immune system.“
„T-cells attack harmful cells, such as cancers. Photo: Shutterstock“
„“More and more people compare it to HIV,” said the doctor who requested not to be named due to the sensitivity of the issue.
In February, Chen Yongwen and his colleagues at the PLA’s Institute of Immunology released a clinical report warning that the number of T cells could drop significantly in Covid-19 patients, especially when they were elderly or required treatment in intensive care units. The lower the T cell count, the higher the risk of death.
Covid-19 virus can produce more than thrice as many pathogens than Sars strain
12 Apr 2020
This observation was later confirmed by autopsy examinations on more than 20 patients, whose immune systems were almost completely destroyed, according to mainland media reports.“
„The study suggests coronavirus can infect T cells. Photo: ShutterstockThe study suggests coronavirus can infect T cells. Photo: Shutterstock
The study suggests coronavirus can infect T cells. Photo: Shutterstock
The coronavirus that causes Covid-19 could kill the powerful immune cells that are supposed to kill the virus instead, scientists have warned.
The surprise discovery, made by a team of researchers from Shanghai and New York, coincided with frontline doctors’ observation that Covid-19 could attack the human immune system and cause damages similar to that found in HIV patients.
Lu Lu, from Fudan University in Shanghai, and Jang Shibo, from the New York Blood Centre, joined the living virus, which is officially known as Sars-CoV-2, on laboratory-grown T lymphocyte cell lines.
T lymphocytes, also known as T cells, play a central role in identifying and eliminating alien invaders in the body.
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They do this by capturing a cell infected by a virus, bore a hole in its membrane and inject toxic chemicals into the cell. These chemicals then kill both the virus and infected cell and tear them to pieces.
Deadly coronavirus comes in three variants, researchers find
12 Apr 2020
To the surprise of the scientists, the T cell became a prey to the coronavirus in their experiment. They found a unique structure in the virus’s spike protein that appeared to have triggered the fusion of a viral envelope and cell membrane when they came into contact.
The virus’s genes then entered the T cell and took it hostage, disabling its function of protecting humans.
The researchers did the same experiment with severe acute respiratory syndrome, or Sars, another coronavirus, and found that the Sars virus did not have the ability to infect T cells.
CORONAVIRUS UPDATE
The reason, they suspected, was the lack of a membrane fusion function. Sars, which killed hundreds in a 2003 outbreak, can only infect cells carrying a specific receptor protein known as ACE2, and this protein has an extremely low presence in T cells.
Further investigations to the coronavirus infection on primary T cells would evoke “new ideas about pathogenic mechanisms and therapeutic interventions,” the researchers said in a paper published in the peer-reviewed journal Cellular & Molecular Immunology this week.
T-cells attack harmful cells, such as cancers. Photo: Shutterstock
T-cells attack harmful cells, such as cancers. Photo: Shutterstock
A doctor, who works in a public hospital treating Covid-19 patients in Beijing, said the discovery added another piece of evidence to a growing concern in medical circles that the coronavirus could sometimes behave like some of the most notorious viruses that directly attack the human immune system.
Read more
South Korean scientists map coronavirus genome, paving way for vaccine and better tests
South Korean scientists map coronavirus genome, paving way for vaccine
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Coronavirus that causes Covid-19 can produce more than three times as many pathogens than Sars strain, HKU study reveals
Covid-19 virus can produce more than thrice as many pathogens than Sars strain
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Coronavirus vs the human immune system: the brutal microscopic war for survival
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“More and more people compare it to HIV,” said the doctor who requested not to be named due to the sensitivity of the issue.
In February, Chen Yongwen and his colleagues at the PLA’s Institute of Immunology released a clinical report warning that the number of T cells could drop significantly in Covid-19 patients, especially when they were elderly or required treatment in intensive care units. The lower the T cell count, the higher the risk of death.
Covid-19 virus can produce more than thrice as many pathogens than Sars strain
12 Apr 2020
This observation was later confirmed by autopsy examinations on more than 20 patients, whose immune systems were almost completely destroyed, according to mainland media reports.
Coronavirus: pandemic hits a grim milestone as Covid-19 deaths worldwide surpass 100,000
Doctors who had seen the bodies said the damage to the internal organs was similar to a combination of Sars and Aids.
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The gene behind the fusion function in Sars-CoV-2 was not found in other coronaviruses in human or animals.
But some deadly human viruses such as Aids and Ebola have similar sequences, prompting speculation that the novel coronavirus might have been spreading quietly in human societies for a long time before causing this pandemic.
Volunteers needed for second phase of China coronavirus vaccine trial
10 Apr 2020
But there was one major difference between Sars-CoV-2 and HIV, according to the new study.
HIV can replicate in the T cells and turn them into factories to generate more copies to infect other cells.
But Lu and Jiang did not observe any growth of the coronavirus after it entered the T-cells, suggesting that the virus and T-cells might end up dying together.
The study gives rise to some new questions. For instance, the coronavirus can exist for weeks on some patients without causing any symptoms. How it interacted with the T cells in these patients remained unclear.
Some critically ill patients also experienced cytokine storms, where the immune system overreacts and attacks healthy cells.
But why and how the coronavirus triggers that remains poorly understood.“
Source: https://www.scmp.com/news/china/society/article/3079443/coronavirus-could-target-immune-system-targeting-protective -
YOU ALL COULD HAVE A BETTER LIFE…STOPPT DEN BND UND DIE CIA.
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„YOU ALL COULD HAVE A BETTER LIFE…
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„FREIMAURER SIND DIE SCHLIMMSTEN VERBRECHER, DAMALS WIE HEUTE!!! 132 Aufrufe•27.03.2020“
„Lasst es nicht zu, dass die Psychiatrie weiter leben zerstört, zusammen mit dem Geheimdienst, den Freimaurern, noch kann dieses System gestoppt werden, noch kann es gestoppt werden.“
„Freimaurerei gibt es schon mindestens seit 400 Jahren, die haben genug Zeit gehabt alles zu infiltrieren, das haben sie auch gemacht, die meisten Zeitungen gehören den Freimaurern und selbst das, was den Freimaurern nicht gehört, gehört denen, weil die meisten Leute geldgierig sind und sich bestechen lassen und auf kaufen lassen, wie gesagt haltet Ausschau.“